Antibody discovery

Therapeutic antibodies and nanobodies are among the fastest-growing classes of biologics, yet identifying rare, high-quality binders remains one of the main bottlenecks in discovery.

ModaFlow™ combines high-throughput droplet microfluidics with integrated functional assays to screen millions of individual droplets while preserving genotype–phenotype linkage.

Whether starting from antibody-producing immune cells or DNA libraries for cell-free protein expression, the platform enables rapid identification and recovery of high-value candidates for downstream sequencing and validation.

Multiple Discovery Strategies. One Platform.

Start from immune cells or DNA libraries, ModaFlow™ provides a flexible platform for functional antibody and nanobody discovery.

Cell-based Discovery

From fresh immune cells to lead antibody or nanobody candidates

Fresh immune cells - including PBMCs, splenocytes or hybridomas - are individually encapsulated into picolitre droplets together with assay reagents. During incubation, secreted antibodies are captured and analysed using integrated bead-based or functional assays. Positive droplets are rapidly identified through multiplex fluorescence detection and sorted for downstream recovery, sequencing, cloning and recombinant expression.

Cell-free Discovery

From DNA libraries to functional antibody and nanobody candidates

Generate and screen antibodies, VHHs or other recombinant proteins directly from DNA libraries using cell-free protein expression (IVTT) in droplets. This workflow enables ultra-high-throughput functional screening while maintaining the genotype–phenotype linkage between DNA and the expressed protein, without the need for living cells.

Accelerating Functional Antibodyand Nanobody Discovery

Multiple Discovery Strategies. One Platform.​

Cell-based Discovery​

Cell-free Discovery

Accelerating Functional Antibody
and Nanobody Discovery

Multiple Discovery Strategies. One Platform.

Cell-based Discovery