Cell culture in hydrogel beads
Use millions of picodroplets as bioreactors
Use ModaFlow™ to encapsulate cells (individually or multiple) or bacteria in biocompatible hydrogel beads (e.g. alginate) and culture them for days in their culture media. Hydrogel beads favor cell grow in 3D, e.g. for the formation of spheroïds and organoïds, and for cell amplification.
After culture, the cells can be collected gently out of the hydrogel for further processing.
Compared to classical nozzle extrusion and external gelation, droplet microfluidics generates highly reproducible beads at high throughput.
"The cell concept... is the axis around which the whole of the modern science of life revolves." Paul Ehrlich